Post-polio Syndrome: More Than Just a Lower Motor Neuron Disease Link to Article


Post-polio syndrome (PPS) is a neurological condition that affects polio survivors decades after their initial infection. Despite its high prevalence, the etiology of PPS remains elusive, mechanisms of progression are poorly understood, and the condition is notoriously under-researched. While motor dysfunction is a hallmark feature of the condition, generalized fatigue, sleep disturbance, decreased endurance, neuropsychological deficits, sensory symptoms, and chronic pain are also often reported and have considerable quality of life implications in PPS. The non-motor aspects of PPS are particularly challenging to evaluate, quantify, and treat. Generalized fatigue is one of the most distressing symptoms of PPS and is likely to be multifactorial due to weight-gain, respiratory compromise, poor sleep, and polypharmacy. No validated diagnostic, monitoring, or prognostic markers have been developed in PPS to date and the mainstay of therapy centers on symptomatic relief and individualized rehabilitation strategies such as energy conservation and muscle strengthening exercise regimes. Despite a number of large clinical trials in PPS, no effective disease-modifying pharmacological treatments are currently available. Keywords: postpolio syndrome, PPS, polio, poliomyelitis, neuroimaging, biomarker, clinical trials, motor neuron disease.

As a companion to the “Polio Paul” article in the January/2022 Polio News, here are some links to further reading on this man’s courageous battle to survive and live with the devastating effects of polio. The story of his journey should serve as inspiration to us all!

Meet ‘Polio Paul’ One Of The Last Men Left With An Iron Lung (

‘Polio Paul’ has spent 7 decades in an iron lung, one of the last in the world: ‘I never gave up’ – pennlive.com


To raise awareness for vaccination and eradication of polio, World Polio Day was established. In 1955, Jonas Salk, the American researcher, led the first team to develop a vaccine against poliomyelitis. To commemorate his birth Rotary international established World Polio Day. Annually World Polio Day is observed on October 24.

World Polio Day offers an opportunity to renew the commitment to eradicate polio, globally. The goal of eradication of polio was first adopted in 1988 and the Global Polio Eradication Initiative (GPEI ) was established. Oral poliovirus was developed by Albert Sabin in 1961, which led to the establishment of GPEI. In 1961 first monovalent oral vaccine was developed which was followed by the trivalent oral polio vaccine in 1963. As of 2013, GPEI had minimised polio worldwide by 99%. Today five out of six WHO regions are certified free of polio. The last stronghold of this poliovirus is in Afghanistan and Pakistan.

To sustain the polio-free status, it is essential to vaccinate all children as per national routine immunization schedules and immediate action is required to be taken if a polios case is detected.

World Polio Day is an ideal time to raise public awareness regarding the devastating effects of polio on children and efforts to eradicate it.

World Polio Day: Theme 2021

The theme of this year is ” One Day. One Focus: Ending Polio – delivering on our promise of a polio-free world”. It is a promise of a polio-free world for current and future generations.


The Late Effects of Polio: An Introduction to Clinical Practice